The man died after being diagnosed with Lassa fever at the Petermaritzburg hospital in KwaZulu-Natal.
According to the National Institute of Infectious Diseases (NICD), the man has a rich travel history.
This includes visiting Nigeria before returning to South Africa. Lassa fever is a viral infection that is endemic to West African countries. It is mainly registered in Sierra Leone, Liberia, Guinea and Nigeria.
The NICD says the man fell ill after entering South Africa and was hospitalized at a hospital in Pietermaritzburg.
The diagnosis of Lhasa fever was confirmed after the man underwent tests. NICD says there are no secondary cases that have been confirmed, however they track and monitor all possible contacts.